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(1996), healthy young volunteers received during four days either placebo or 200 mg of itraconazole, a potent inhibitor of zopiclone CYP3A . Itraconazole significantly increased the maximal blood levels (from 49 to 63 ng/ml) and area under curve of zopiclone, and prolonged the plasma half-life value from 5 to zopiclone 7 h . However, no significant difference was observed in the pharmacodynamic effects of zopiclone after CYP3A4 inhibition, and it was concluded that at least in young adults, such a pharmacokinetic interaction would be of limited clinical zopiclone importance . It thus appears that, for zopiclone use, CYP3A4 inhibition can be clinically relevant together with coinciding additional dopareel 7.5 mg zopiklon kostar zopiclone quick delivery zopiclone indonesia dopareel 7.5 mg factors .

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